The Carolina Reaper is one of the hottest peppers known to man. It hits 2.2 million Scoville units. For perspective, a jalapeño maxes out at a mere 20,000 Scoville units. This is epicly stupid since capsaicin (the part that makes chillis hot) is a potent irritant and the lining of human lungs was by no means designed to be in contact with it. It's why they use the shit as an active ingredient in riot control and personal defense pepper spray agents. When the spray comes in contact with skin, especially eyes or mucous membranes, it produces pain and breathing difficulty, discouraging assailants. https://en.wikipedia.org/wiki/Capsaicin#Pepper_spray_and_pests
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